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Research Paper, Published by CAU Undergraduate Students of Department of Medicine, Appears in Academic Journal

Name 관리자 Date 2017.05.11 Hit 103
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[From left to right: Hwang Jung-hu, Lee Da-bin, Park Byung-ju, Kang Sung-mun, Wi Chung-bum, Ko Won-kyu, Bang Jun-ho, and Prof. Ko Jae-hong]


Undergraduate students of Chung-Ang University (CAU) Department of Medicine conducted research through the year 2016 as part of an activity under their class ‘Experimental Methodology to Nurture Medical Scientists.’ Based on this activity, they published a research paper titled 'Cordycepin induces human lung cancer cell apoptosis by inhibiting Nitric oxide mediated ERK/Slug signaling pathway' in an international academic journal, American Journal of Cancer Research (IF: 3.425, JCR 2015).

 

Seven first-year medical students, through their research, first found out that cordycepin serves as an inhibitor to an activation in lung cancer cells by inhibiting Nitric Oxide (NO)–the main cause of creating an inflammatory response and tumor in lung cancer cell lines A549 and PC9–mediated ERK/Slug signaling pathway, with the joint support of Prof. Ko Jae-hong of the Basic Research Laboratory under CAU Department of Medicine and Dr. Jang Ik-soon of the Korea basic Science Institute.


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[Schematic diagram which demonstrates a role of Cordycepin in inhibiting NO mediated ERK/Slug signaling pathway]



The research team said that their research achievement would be utilized to understand lung cancer pathogenesis and furthermore laid the foundation for developing a treatment for some lung cancer.


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