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CAU Research Team Led by Professor Hong Jin-gi Featured on Cover of Journal Small

Name 관리자 Date 2016.12.20 Hit 606
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[CAU Professor Hong Jinkee and PhD candidate Jeong Hyejoong]

  

Chung-Ang Univeristy(CAU) researchers made the cover of a prestigious journal. Professor Hong Jin-gi(School of Chemical Engineering and Material Science) and Phd candidate Jeong Hye-joong conducted a joint research with Professor Francesco Ricci of University of Rome Tor Vergata, and their research titled “Electronic Activation of a DNA Nanodevice Using a Multilayer Nanofilm” was featured in the most recent issue of Small, a renowned journal in the field of nanotechnology. (http://onlinelibrary.wiley.com/doi/10.1002/smll.201670204/full)



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[Cover page of Small journal]

   


CAU researchers and Italian researchers under professor Ricci worked together on the Korea - EU Joint Research Program supported by the Ministry of Science, ICT and Future Planning.


DNA has become one of the most important biological materials: its ability to self-assemble in a highly predictable manner, its low synthesis cost and biocompatibility have been utilized to develop a variety of nanostructures and functional DNA-based nanodevices for biomedical applications. DNA nanodevices are nanomechanical supramolecular structures which can perform a variety of tasks and nanoscale movements, and can be applied in the areas of diagnosis, biosensing, bioimaging, and drug delivery.


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[schematic illustration of multilayer film and activation of nonodevices using electronic inputs]


However, the complementary bonding nature of DNA strands makes it difficult to control the activation of a DNA nanodevice. To make a better control of activating DNA-based nanodevices, the researchers prepared a multilayer nanofilm on the surface of a chip-electrode using a layer-by-layer (LbL) assembly method, and regulated the spontaneous activation of DNA nanodevices.

 

In this study, we demonstrated a method to regulate the spontaneous activation of DNA nanodevice by introducing on demand cDNA release system of an electroresponsive multilayer nanofilm. To the best of our knowledge, this is the first attempt to adjust DNA nanodevice using multilayer nanofilm. On the basis of our report dealing with the most basic form of DNA nanodevice, we can modulate it into more advanced forms using other kinds of triggers or functional DNA-based nanodevices including various functions such as drug delivery, pH-responsibility, and enzyme or gene detection for biomedical applications. We believe our approach can provide a new platform to DNA-based nanodevices”, Professor Hong said.

 

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