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CAU Professor Wonyong Kim Finds Protective Effects of New Lactococcus Lactis Against Atopic Dermatitis

Name 관리자 Date 2016.12.06 Hit 621
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Chung-Ang University research team led by professor Wonyong Kimfound the protective effects of Lactococcus chungangensis CAU 28T against atopic dermatitis. The CAU research team discovered a new strain of Lactococcus lactis back in 2008, and name it “Chungangensis” after Chung-Ang University. Their study was covered in the September issue of the Journal of Dairy Science Agriculture, one of the most prestigious journals in the field of Dairy and Animal Science. In particular, the study was featured in the 'Editor's Choice section which includes the most important articles and papers. 


Atopic diseases have increased markedly in prevalence across the globe, but the efficacy of existing medicine/therapy is short-lived and often causes side effects when taken long term.

 

Focusing on the fact that atopic dermatitis is associated with malfunction of the body's immune system, CAU researchers studied the protective effects of Lactococcus chungangensis against atopic dermatitis. The results showed that L. chungangensis CAU 28T exhibited potent antiinflammatory activity by inhibiting the production of the proinflammatory mediators nitric oxide and prostaglandin E2. Treatment with L. chungangensis CAU 28T also reduced the release of β-hexosaminidase and histamine.

 

In addition, oral administration of L. chungangensis CAU 28T suppressed the production of IL-4, IL-5, IL-12, IFN-γ, tumor necrosis factor-α, and thymus- and activation-regulated chemokine (TARC) in skin lesions, indicating that it strongly drives the local immune system with efficacy comparable to that of a topical immunomodulatory drug used for the treatment of atopic dermatitis. The findings indicate that L. chungangensis CAU 28T could be a novel probiotic candidate for controlling the symptoms of atopic dermatitis. The researchers are planning to develop functional foods using Lactococcus chungangensis.  


“I want to share this joy with my fellow researchers. We have applied for a patent related to the study at home and abroad, and will do what is necessary to best benefit the patients with atopic dermatitis”, said professor Kim.



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이전글/다음글 보기
이전글 CAUH Professor BI Choi Invited as Guest Speaker at Harvard Medical School’s Forum 2016.11.13
다음글 CAU Ranked 7th in 2016 Joongang Ilbo Comprehensive University Assessment, up from 8th last year 2016.12.02

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